Pulmonary arterial hypertension (PAH) is a rare and progressive disorder of the lungs that causes high blood pressure in the arteries of the lungs. It is a serious and potentially life-threatening condition that can lead to severe disability and even death. The condition occurs when the walls of the pulmonary arteries become thickened and stiffened, forcing the heart to work harder to pump blood through them.

The exact cause of PAH is not known, although it is believed to be caused by a combination of genetic factors, environmental factors, and certain medical conditions. Risk factors for developing PAH include having certain genetic mutations, being exposed to certain toxins or medications, and having certain medical conditions such as connective tissue disorders and HIV infection.

The most common symptom of PAH is shortness of breath, especially during physical activity. Other symptoms can include fatigue, chest pain, dizziness, and swelling in the legs and feet. In advanced cases, people with PAH may experience right-sided heart failure, a type of heart failure that can be life-threatening.

PAH is usually diagnosed with the help of a combination of tests, such as echocardiography, right-heart catheterization, and pulmonary function tests. Treatment for PAH can vary depending on the severity of the condition, but often includes medications that help relax the blood vessels to reduce the pressure in the lungs, as well as medications that work to improve the function of the heart. In some cases, a lung or heart transplant may be necessary.

Living with PAH can be difficult, but with proper medical care and lifestyle changes, it is possible to manage the condition and improve quality of life. It is important to work closely with your doctor to make sure that your condition is being properly managed and to keep up with treatment.

Medication to treat

Endobloc 5mg tablet contains the active ingredient ambrisentan. It belongs to the diphenylmethane derivatives. This medication is used in the treatment of pulmonary arterial hypertension, this is caused due to the high blood pressure in the blood vessels from the heart to that of lungs. Endobloc 5mg tablet works by relaxing the blood vessels and increases the blood supply to the lungs.