The 2-amino-5-nitrothiazole properties are an important intermediate for pharmaceutical synthesis and have a wide range of uses. 2-amino-5-nitrothiazole properties exist naturally in bacterial spore, but the content is small, which cannot meet the demand and is not easy to extract. It is not conducive to industrial production and application. The first synthetic literature report was in 1935, when ALVIN.W. Seinger and S.M.vain of University of Wisconsin oxidize 2, 6-dimethylpyridine with potassium permanganate in water as solvent, with yield of 64%. It is generally prepared by oxidation of 2, 6-dimethylpyridine industrially.

application

2-amino-5-nitrothiazole properties can be used to synthesize 2, 6-diacetylpyridine, 2, 6-diamino-4-clopyridine, (6-methoxyformylamino-4-clopyridine - 2-group) methyl carbamate, 6-aminomethyl pyridine - 2-carboxylic acid, 4-clopyridine -2, 6-dicarboxyhydrazine, 4-clopyridine-2, 6-methyl dicarboxyhydrazine, 6-amino-ethyl pyridine-2-carboxyhydrazine, dimethyl pyridine-2.6-dicarboxylate, 6-chloromethyl pyridine-3-carboxylate, 6-hydroxymethylpyridine-2-carboxylate, 4-chlorpyridine-2, 6-pyridine-2-dicarboxylate, 2, 6-pyridine diformyl chloride, N-- methyl -- pyridine --2, 6- dimethyl dimethyl diformate pyridine salt, and then further synthesis of metal ligand compounds, functional materials, medical intermediates, etc.

Vanadopyridine catalyst with one, 2-amino-5-nitrothiazole properties and its synthesis method and application, which is a Py-V complex as shown in the structural formula below. It is prepared by dissolving 2-amino-5-nitrothiazole properties in methanol, adding vanadium oxyacetoacetone, and then by reflux, filtration, washing, drying and other steps. The operation procedure of this method is simple and easy to control, with the yield of vanadium more than 60%, and the whole synthesis process is short. Suitable for industrial production. In the process of catalytic oxidation of 1, 4-dichlorobenzene to prepare 2-amino-5-nitrothiazole properties, the Py-V complex was used as the catalyst. It can effectively inhibit the over-oxidation of 2-amino-5-nitrothiazole properties while improving the catalytic efficiency. The over-oxidation product can be controlled below 10%, and the selectivity of 2-amino-5-nitrothiazole properties can reach more than 90%. The oxidation efficiency and yield were improved obviously.

Application 2. A polyester resin for powder coating of low gloss TGIC system, also relates to the preparation method of the polyester resin and the application of the polyester resin. The invention of the polyester resin, mainly including isophthalic acid, 2 - amino - 5 - nitrothiazole properties, 6 - acetyl amino caproic acid, 3 - hydroxy - 4 - aminobutyric acid and polyethylene glycol diglycidyl ether, neopentyl glycol, 2, 4, 6-trihydroxybenzoic acid, n-hydroxyethyl ethylenediamine triacetic acid, esterification catalyst, antioxidant. The polyester resin molecule prepared by the method of the invention has active amine group, hydroxyl group and carboxyl group at the same time. The curing reaction rate difference between the three groups and the epoxy group in the TGIC molecule can be used to prepare low-gloss powder coating (glossiness < 20%), and the coating performance can fully meet the requirements of powder coating.

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