Tapentadol for toothache Tapentadol is an opioid analgesic, which means it relieves pain by acting on the central nervous system. Tapentadol for toothache has a small indication of dentistry for the treatment of acute pain. It binds to the -opioid receptor on nerves and prevents two neurotransmitters, serotonin and norepinephrine, from being reabsorbed by nerves. Within 30 to 60 minutes,...